For 15 years, ER ruled the airwaves as it followed the drama-filled lives of doctors working at the fictional County General Hospital based in Chicago. The Michael Crichton-created series premiered in September 1994 and ran until April 2009, airing 331 episodes of TV during its time on NBC.

“People talk about numbers when you talk about American Idol or whatever the big one is — 16, 17 million people,” George Clooney, who portrayed Doug Ross in the show, told the The Hollywood Reporter about ER‘s success. “We were averaging 40 million people at 10 o’clock at night with an hour show. That made a huge difference in my career. It really changed things.”

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The 57-year-old had a blast at the time, noting that ER being a very “nutty moment” and career-altering gig. “There was six of us who were thrown into the stratosphere,” he recently told Fox News. “It was life-changing for all of us.”

Now as a dad-of-two, George is ready for the new Hulu miniseries, Catch-22, to drop. When he’s not working, you can find him spending some quality time with his family — including wife Amal Clooney.

Scroll below to see what the cast of ER is up to now!

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