Ellen — who received a Golden Globe nomination in 2007 for her portrayal of Meredith — continues to appear on the show today. The mom-of-three's notable film credits include Moonlight Mile, Old School, Daredevil, and Catch Me If You Can.
Justin is one of few original cast members to still be on the show after more than 10 years. Though he is most recognized for playing Dr. Karev, he has also starred in movies Broken City, The Zodiac, and The Wedding Planner.
Since her run on Grey's came to an end in 2010, Katherine landed leading roles in movies Life as We Know It, New Year's Eve, and The Big Wedding. The mom-of-three — who is married to musician Josh Kelley — was starring on the NBC drama State of Affairs, but the show was recently canceled.
The mom-of-three's film credits include Philadelphia, Lone Star, and A Single Woman. In addition to Grey's, the star has also appeared on TV shows The Cosby Show, Law & Order: Special Victims Unit, and The Sopranos, among others.
James is widely known for playing Dr. Webber on Grey's and Deputy Director Alvin Kersh on The X-Files. He has been awarded a SAG Award for his performance on the medical drama, which he continues to star on today.
The actress' most memorable performance was in the 1991 horror film The Silence of the Lambs. After leaving the medical drama after 25 episodes in 2008, Brooke guest starred on Criminal Minds, Law & Order: Special Victims Unit, and American Horror Story: Asylum.