Finally!Ellen Pompeo and Justin Chambers Reveal How They Feel About Meredith and Alex’s Relationship on ‘Grey’s Anatomy’

Ellen Pompeo and Justin Chambers have finally spoken out about the fate of their relationship on Grey’s Anatomy!

The long-time co-stars opened up in a new interview about how they feel about the chemistry between their characters, Meredith Grey and Alex Karev, on popular series — and fans may be saddened by what they revealed about one of television’s favorite pairs!

ellen pompeo justin chambers getty images

Ellen and Justin on Grey’s.

Following the death of Meredith’s husband, Dr. Derek Shepherd (portrayed by Patrick Dempsey) during Season 12, fans were immediately suspicious that a love affair may be in the future for Mer and Alex. But, they unfortunately think otherwise.

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“Justin is one of my favorite people on the planet,” Ellen, 47, told E! News on the Grey’s set. “We’re really close, and it does feel weird. To potentially maybe have him as a love interest would be like kissing my brother. I used to say that about Patrick all the time too because just we’d been together for so long.” Ellen and Justin have both been on the show since its first season in 2005.

“The love interest part is not my favorite piece of this, I’ll be honest,” she added. “Kissing guys that aren’t your husband is, you know, a little weird. I guess it wouldn’t be if you didn’t like your husband, but I happen to be very, very fond of mine.”

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While Justin, 46, agrees with Ellen, he doesn’t like to rule things out, as he knows the show’s creator, Shonda Rhimes, can have anything up her sleeve! “I think anything is possible, but personally I find it to be weird,” he confessed to the news outlet. “I think that they’re very much like siblings. They’ve been through so much together. Personally, I don’t see it. But, hey, this is Grey’s Anatomy. Anything is possible.”

Click through the gallery below to see the cast of Grey’s Anatomy then and now!