Chelsea Handler ended seven years as host of the E! talk show, Chelsea Lately, on Tuesday night with help from dozens of A-listers!

"I've made great friends, a lot of enemies, and I have personally lost and gained 3,500 pounds," the 39-year-old joked before welcoming guests like Jennifer Aniston, Sandra Bullock and even ex, 50 Cent. Miley Cyrus also performed, though hers wasn't the only performance of the night!

A huge group of stars, including Gwen Stefani, Fergie, Gerard Butler, Tim Allen and Selena Gomez, joined the long-time host to belt out an original tune entitled, "Goodbye to E!"

"It's time to move on. [Chelsea] wants to sing. She wants to dance and get her groove on," they sang. “She can’t go on faking every day. If Chelsea cares about Kim and Kanye."

The show also included a hilarious pre-taped video featuring a nude Chelsea chatting with Ellen DeGeneres in a shower. The 56-year-old desperately wanted to know why she'd never been invited on Lately.

Next up for the blonde beauty: a move to the streaming service, Netflix, where a stand-up special starring the comedian is set to air next month. Chelsea will also host the site's first ever talk show, though a start date has not yet been released.