Happy 50th Birthday, Patrick Dempsey!
To celebrate Dr. McDreamy's special day, click through our gallery above to see the Grey's Anatomy cast — including Ellen Pompeo, Sandra Oh and more! — then and now.
Ellen — who received a Golden Globe nomination in 2007 for her portrayal of Meredith — continues to appear on the show today. The mom-of-three's notable film credits include Moonlight Mile, Old School, Daredevil, and Catch Me If You Can.