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These 28 Derek Shepherd Quotes From 'Grey's Anatomy' Will Totally Make You Sob

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Usually, we loved Derek Shepherd on Grey's Anatomy, but sometimes, not gonna lie, we wanted to scream at McDreamy. But no matter how we were feeling about the surgeon, there's no denying one thing — Dr. Shepherd had some seriously profound things to say on the show. The best part? His onscreen wife, Meredith Grey, had some awesome quotes, too! Missing Derek on Grey's as much as we are? Scroll down to see McDreamy's best quotes!

"The first time I kissed my wife, she wasn't my wife then, she was just this girl in a bar. But when we kissed, it was like, I gotta tell you, it was like I'd never kissed any other woman before. It was like my first kiss. The right kiss."

"It's a beautiful day to save lives."

To Meredith: "You were like coming up for fresh air, like I was drowning, but you saved me."

Amelia: "I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me." Derek: "It wouldn't be love if it didn't."

To Meredith: "I don't want 48 uninterrupted hours, I want a lifetime."

Meredith: "It seems like you came home because you thought you were in trouble. Derek: "I came home because we're in trouble. I came home to work on us. I came home."

"We know that every connection matters. Every connection is crucial and when one is broken, it usually means that the damage has been done. This system of connection compels us to act, choose and behave... sometimes seemingly against our own will, but it is not random at all. It is the map of who we are. We will work to understand ourselves... solve the puzzle of how all the connections work and how all the pieces fit."

"You are so sexy when you are looking at a teratoma."

Derek: "Come back to me." Meredith: "What's to miss in Neuro?" Derek: "Me."

"You know, I was holding her yesterday, and she was crying and then she stopped. And I've held a lot of babies; I've fixed a lot of babies. But, I looked down at Zola, and I don't know what it was, but I just couldn't imagine her being with any other parent or any other family. We've been trying so hard to start a family, and she needs one. Let's adopt her. I'm serious, let's adopt her."

"I'm a human being, I make mistakes, I'm flawed, we all are."

"You and me. It is not the thrill of the chase. It’s not a game. It’s... it’s your tiny ineffectual fists. And your hair... It smells good. And you’re very, very ballsy. It keeps me in line."

"You don’t kiss someone by puckering your lips. You see someone and you remember why you desire them. Your sympathetic nervous system quickens your pulse, your frontal lobe lowers your inhibition, and you need to kiss them. It happens all at once. We’re impulsive and compulsive, that’s how the brain works."

"You know what's really fun and not at all depressing? Alzheimer's research."

Meredith: "I'm too mad to even look at you." Derek: "Then roll over."

"Breakthroughs don't happen because of the medicine. Real breakthroughs happen because someone is scared to death to stop trying."

"Yes or no. In or out. Up or down. Live or die. Hero or coward. Fight or give in. I'll say it again to make sure you hear me. The human life is made up of choices. Live or die. That's the important choice. And it's not always in our hands."

"That is how a Chief does things. Take note."

"If you don't feel the losses... that's when you know you're not cut out for this kind of work."

"We ask a lot of our patients. We put them to sleep. Cut them open. Poke around in their brain and guts with sharp instruments. We ask for their blind trust. Irony is, trust is hard for surgeons, because we're trained from day one that we can't trust anyone but ourselves. The only instincts you can count on are your own. The only skills you can count on are your own. Until one day, you leave the classroom and step into the O.R. You're surrounded by others, a team of others. A team that you have to rely on whether you trust them or not."

"Ask most surgeons why they became surgeons and they usually tell you the same thing. The high, the rush, the thrill of the cut. For me it was the quiet. Peace isn't a permanent state. It exists in moments. Fleeting. Gone before we knew it was there."

Meredith: "Just a normal day." Derek: "Normal day. Going to work." Meredith: "Just a normal day, that ends in a ceremony in a churchy church." Derek: "This has nothing to do with us, we're just the bride and groom." Meredith: "We're getting married tonight." Derek: "We're getting married tonight."

"You know one of the joys of cohabitation is having breakfast together."

"You broke her. You called her ordinary. You told her time and time again that nothing she does ever is good enough. Every good thing Meredith is happened despite you. She may not survive this. That's on you. That is on you!"

"You deserve to be with somebody who makes you happy. Somebody who's not gonna complicate your life. Somebody who won't hurt you."

"I'm not going to stop loving you, Meredith. I can live without you, but I don't want to live without you. And I'm going to do everything in my power to prove it."

Girl: "Oh my god, I'm gonna die." Derek: "Stop saying that. It's insulting. I don't let people die. I'm very good at my job. Even next to the roadside."

To Meredith: "I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you."

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